Set in a post-apocalyptic world in which a virus has wiped out most of humanity, with survivors being terrorized by roaming scavengers called "Reapers." The protagonist is Hig, a pilot who survived the flu that killed everyone he knew, his wife included. He lives in the hangar of a small abandoned airport with his dog, his only neighbor a gun-toting ex-Marine. Hig sometimes heads off in his 1956 Cessna, where he can fish and pretend things are how they used to be. When a random transmission somehow beams through his radio, the voice ignites a hope deep inside him that a better life might exist if he flies a bit further. He risks it all. to chase a possible haven in Grand Junction.
After decades of being blown to bits by bombs, demolished by dynamite, mangled by magnets, battered by boulders, trampled by trains, tricked by tunnels, sprung by springs, steamrolled by steamrollers, maligned by misfires, bedeviled by bungees, rattled by rockets, backstabbed by bat suits, rocked by rocket skates, upended by unicycles, quaked by quake pills, rubberized by rogue bands, and hurled headlong off every cliff in the Southwest, Wile E. Coyote (Genius) finally fights back. Teaming up with billboard accident lawyer Kevin Avery (Will Forte), he takes on slick corporate counsel Buddy Crane (John Cena) and ACME, Inc., the profit-obsessed conglomerate behind every one of the Coyote’s chaotic catastrophes.